The Los Angeles Times reported in 1985 that "the band gets sullen fans of Twisted Sister cheering and poking stubby 'one way' fingers heavenward - a refutation of the double-fingered 'devil horns' salute of many metal groups".

In the 2009 film Whip It, Ellen Page's character "Bliss" distinctively wears a Stryper t-shirt throughout the film.

The song "To Hell With The Devil" appears on the Rhino Records release The Heavy Metal Box, a compilation mainly of secular classic metal bands like Iron Maiden, Judas Priest, and Metallica, as well as hair bands like Twisted Sister and Poison.

Ian Christe, author of the heavy metal history book Sound Of The Beast: The Complete Headbanging History Of Heavy Metal, mentions the album To Hell With The Devil in his book as one of the landmarks of the glam metal movement.

Stryper stands for Salvation Through Redemption Yielding Peace, Encouragement and Righteousness. The Isaiah 53:5 under their logo is the bible verse that states "by His stripes we are healed".

Stryper, originally known as Roxx Regime, was formed in Orange County, California by brothers Michael and Robert Sweet and guitarist Oz Fox.